Gallone G, D'Ascenzo F, Conrotto F, et al. - Among 3,002 patients receiving unprotected left main (ULM)/bifurcation PCI with very thin strut stents, the PARIS risk score (PARIS‐rs) (classified as low, intermediate, and high) and percutaneous coronary intervention complexity (PCI‐c) (as per guideline‐endorsed criteria) were assessed in terms of predictive performances for clinical and procedural residual ischemic risk post-PCI. Following 16 (12–22) months, an association of increasing PARIS‐rs and PCI‐c with higher rates of major adverse cardiac events (MACE) was evident, driven by MI/death for PARIS‐rs and target lesion revascularization/stent thrombosis for PCI‐c. Findings revealed that a better prediction of residual ischemic risk in the setting of ULM/bifurcation PCI was enabled by a clinical risk estimator vs by PCI complexity, which rather seemed to reflect stent/procedure‐associated events. There is required careful procedural risk assessment in cases with low clinical risk, where PCI complexity may substantially add to the overall residual ischemic risk.