Simon K, et al. - Using the latest software algorithm in urban radiology practice, researchers compared the diagnostic performance of synthetic 2D imaging generated from 3D tomosynthesis (DBT) with traditional 2D full-field digital mammography (FFDM). The cohort comprised all biopsy-proven breast cancers detected during the study period with screening mammography (n = 89) and 100 cases of negative or benign findings (BI-RADS category 1 or 2) after 365 days of follow-up. According to findings, DBT plus synthetic 2D mammography performs in diagnostic accuracy (sensitivity, specificity, positive predictive value, or negative predictive value) measures as well as and not worse than DBT plus FFDM and can be a viable alternative to decreasing radiation dose without sacrificing diagnostic performance.