Narayen IC, et al. - The accuracy of pulse oximetry screening for critical congenital heart defects (CCHDs) in home births and early discharge after hospital deliveries was determined. Pulse oximetry screening adapted for perinatal care in home births and early postdelivery hospital discharge was shown to be useful in the diagnosis of CCHDs before signs of cardiovascular collapse. High prenatal detection gave rise to a moderate sensitivity of pulse oximetry screening. Moreover, the screening identified non-cardiac illnesses in 0.6% of all infants, with the inclusion of infections and respiratory morbidity. This, in turn, resulted in early detection and referral for treatment.