Chalmers BP, Kapadia M, Chiu YF, et al. - This study was undertaken to investigate the predictive value of the CRIME80 and KLIC for the failure of debridement, antibiotics, and implant retention (DAIR) in acute hematogenous (AH) and acute postoperative (AP) PJIs, respectively. Researchers distinguished 134 patients that had undergone DAIR for AH periprosthetic joint infection (PJI) with < 4 weeks of symptoms after index arthroplasty and 122 patients that underwent DAIR for AP PJI < 90 days from the index. To the authors’ knowledge, in a North American population, this study represents the first external validation of the KLIC and CRIME80 for predicting DAIR failure. The outcomes demonstrate that alternative methods for predicting DAIR failure at 90 days and 2 years for acute PJI are required.