Hagström H, et al. - In a retrospective analysis of data from 646 patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD), recruited from 2 hospitals in Sweden, from 1971 through 2009, researchers investigated the relationship between 4 scoring systems [NAFLD fibrosis score (NFS), FIB-4, APRI, and BARD scores] and incident severe liver disease and overall mortality. Investigators found the NFS and the FIB-4 scores to most precisely determine the risk of overall death or severe liver disease in a large cohort of patients with biopsy-proven NAFLD. The area under the receiver operating characteristic (AUROC) values for these scoring systems, however, are not sufficiently high for clinical use. In order to determine NAFLD patient prognoses, new systems are needed.