Borggrefe J, et al. - For the separation of vertebral trabecular bone metastases (BM) from the healthy-appearing trabecular bone (HTB), investigators assessed quantitative iodine density mapping (IDM) with spectral detector computed tomography (SDCT) as a quantitative biomarker in 43 consecutive cancer patients with BM and 40 without BM. A statistical separation of vertebral bone lesions from HTB was calculated by IDM of SDCT. Enhancement in discrimination of trabecular lesions was done woth adjustment for confounders such as age and lumbar vBMD, as well as for vertebral venous iodine density and lesion heterogeneity.