Borggrefe J, et al. - The investigators performed retrospective single-center-study to estimate the quantitative iodine density mapping (IDM) with spectral detector computed tomography (SDCT) as a quantitative biomarker to separate vertebral trabecular bone metastases (BM) from healthy-appearing trabecular bone (HTB). Multivariate ROC analyses and Wilcoxon test were employed to ascertain the thresholds for separation of BM and HTB. It was observed that iodine density measured in SDCT yielded highest sensitivity and specificity for the statistical differentiation of vertebral trabecular metastases and healthy trabecular bone. They concurrently found that age and volumetric bone mineral density (vBMD) had an important influence on iodine density measurements.