Fernández–Sampedro M, et al. – Authors sought to characterize the accuracy of individual or group tests, such as culture of sonicate fluid, synovial fluid and peri–implant tissue, C–reactive protein (CRP) and histopathology for detection of early, delayed and late prosthetic joint infection (PJI). In this work, sonicate fluid and peri–implant tissue cultures achieved the same best sensitivity for early PJI. For delayed and late PJI, sonicate fluid culture proved the most sensitive individual diagnostic method. By combining histopathology and peri–implant tissue, all early, 97% of delayed and 94.8% of late cases were diagnosed. For all types of infection, the conjunction of histopathology and sonicate fluid culture yielded a sensitivity of 100%.