Cannavò L, et al. - Resected primary malignant bone tumor specimens removed from 46 patients were imaged using magnetic resonance imaging (MRI) and computed tomography (CT) immediately post-surgery by the researchers in order to assess the correctness of MRI and CT in evaluating the resection margins of primary malignant bone tumors. Reproducibility of the radiologist varied from moderate to substantial for bone and soft-tissue margins on CT, respectively, whereas that of the orthopaedist ranged from fair to moderate, holding histology as the reference standard. Ranging from substantial to perfect, reproducibility of readers' assessment of bone margins elevated when comparing R2 (macroscopic residuals) and R0 (safe margins) + R1 (residuals between 0 and 1 mm) scores, while inter-reader agreement varied from fair to substantial. The correctness of the radiologist ranged from 76% to 83% and for orthopaedist, it ranged and from 68% to 72%. The exactness of both readers ranged from 83% to 100% when R2 and R0+R1 scores were contrasted. However, no correlation among local recurrence and margin scores of histology, MRI, and CT was found. Therefore, for extemporaneous investigation of resection margins of primary malignant bone tumors, MRI and CT could be helpful, although wide accuracy variability among the different imaging methods was noted.