Shiroshita A, Oda Y, Takenouchi S, et al. - Findings from this systematic review suggest high sensitivity and specificity of anti-glomerular basement membrane (GBM) antibodies in the diagnosis of anti-GBM disease.

• Using MEDLINE, Embase, the Cochrane Library, and the International Clinical Trials Registry Platform, researchers identified six studies (1,691 patients) and 11 index tests for inclusion in the systematic review.

• As 67% of the included studies had case-control design, a high risk of bias and concerns regarding the applicability of patient selection were noted.

• The pooled sensitivity was 93% and specificity was 97%.

• The high risk of bias and indirectness indicates a low certainty of evidence.