Wu Z, Liang Y, Li Z, et al. - In this retrospective and observational cohort study, researchers included children admitted for infection to China's pediatric intensive care unit (PICU) between January 1, 2009 and December 31, 2017, to seek validation for the accuracy of age-adapted Sequential organ failure assessment (SOFA) and systemic inflammatory response syndrome (SIRS) in predicting the poor prognosis among these individuals. Overall 1,831 children admitted to PICU because of infection were included. The observed accuracy of age-adapted SOFA score of ≥ 2 was more than that of SIRS criteria in predicting in-hospital mortality of PICU-admitted children. Also, the former yielded a higher sensitivity in identifying children with severe infection.