Kim HJ, et al. - Via an institutional review board approved prospective study of fat-water phantom and 20 adult-nonalcoholic fatty liver disease patients, the researchers intended to determine linearity, bias, repeatability, and reproducibility of the proton density fat fraction (PDFF) measurement using complex-based chemical shift imaging-based magnetic resonance imaging (CSE-MRI) (CSE-PDFF) across scan intervals, MR field strengths, and readers. CSE-PDFF was observed as a robust quantitative imaging biomarker with high linearity, small bias, and exceptional repeatability/reproducibility. Therefore, a change of more than 3 PDFF% across field strengths within 2 weeks of scan period would possibly reflect a true change, which is well within the clinically acceptable range.