Frazee BW, et al. - Researchers sought to compare the accuracy and discomfort of different types of intranasal specimen collection methods for molecular influenza testing in Emergency Department patients. Researchers observed that midturbinate swab specimens provided a significantly more comfortable sampling experience, with only a small sacrifice in sensitivity for influenza detection, when compared with the reference standard nasopharyngeal swab specimen. Nasal swab specimens seemed markedly less sensitive than midturbinate swab. Thus for molecular influenza testing in Emergency Department (ED) patients, the midturbinate swab seemed to be the sampling method of choice.