Cauley JA, et al. - Using high-resolution peripheral quantitative computed tomography scans, researchers conducted this cross-sectional study to evaluate the premise that accelerated bone loss (ABL) shown on routine dual-energy X-ray absorptiometry might be accompanied by microarchitectural changes, increased cortical porosity, and lower bone strength. For this investigation, they analyzed 1,628 men who attended the year 14 exam of the Osteoporotic Fractures in Men study. Compared with men without ABL, those with ABL had lower estimated bone strength, poorer trabecular microarchitecture, and thinner cortices. However, no difference was found in cortical porosity except at the tibia diaphyseal site. Evidence suggested that these impairments may result in an increased risk of fracture.