Mauermann E, et al. – This study was performed in patients undergoing on–pump cardiac surgery to investigate the link between isolated second–postoperative–day B-type natriuretic peptide (BNP) concentrations, second–day BNP concentrations in conjunction with first–day BNP concentrations, and the change in BNP (ie, ΔBNP) from the first to the second postoperative day and 12–month, all–cause mortality. Findings revealed that 12–month, all–cause mortality was independently predicted by both absolute concentrations of first– and second–postoperative–day BNP. When modeled together, 12–month, all–cause mortality was better predicted by second–postoperative–day BNP. In addition, the change in BNP from the first to the second postoperative day was a complex variable and recommended not to be routinely used for prognostication.