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AbobotulinumtoxinA efficacy and safety in children with equinus foot previously treated with botulinum toxin

Pediatric Neurology Feb 14, 2018

Dabrowski E, et al. - An inquiry was set up with regard to the efficacy of botulinum toxin in patients with spastic equinus foot who had received previous injections. Findings disclosed similar abobotulinumtoxinA efficacy and safety profiles in children with spasticity who were new to botulinum toxin treatment and in children who were previously treated. Comparable efficacy and safety of abobotulinumtoxinA treatment were reported in these previously-treated patients with the overall trial cohort. Hence, doses of 10U/kg/leg and 15 U/kg/leg were discovered to be suitable starting doses for children with spasticity, irrespective of the previous botulinum toxin preparation used.
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