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Abnormal placental perfusion and the risk of stillbirth: A hospital-based retrospective cohort study

BMC Pregnancy and Childbirth Apr 23, 2021

Wu JN, Ren YY, Zhu C, et al. - Researchers performed a hospital-based retrospective cohort study to compare the prevalence of stillbirth among the offspring of women with or without abnormal placental perfusion (APP). Between 2012 and 2016, women with a singleton pregnancy (N = 41,632) were analyzed. Multivariate analysis was conducted to contrast the prevalence of stillbirth in infants exposed to APP (defined as any abnormality in right or left uterine artery pulsatility index or resistance index [UtA-PI, −RI] [eg, > 95th percentile] or presence of early diastolic notching) with that in those not exposed to APP. The current study discovered that stillbirth risk was linked to APP (eg, right PI > 1.33 or right RI > 0.69 or left PI > 1.39 or left RI > 0.70 at gestational week 22) and increased with the severity of APP. There are distinct mechanisms between the genders. The performance of stillbirth screening can be improved by stratifying by gender and placental perfusion.

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