Abnormal nailfold capillaroscopy is common in patients with connective tissue disease and associated with abnormal pulmonary function tests
The Journal of Rheumatology Sep 08, 2019
van Roon AM, Huisman CC, van Roon AM, et al. - In patients with Raynaud phenomenon (RP), researchers evaluated the presence of systemic sclerosis (SSc) pattern on nailfold capillary microscopy (NCM) and examined its connection with abnormal pulmonary function tests (PFT), defined as forced vital or diffusion capacity < 70%. For this investigation, they evaluated NCM patterns in 759 consecutive patients with RP. They classified patterns as normal (n = 354), nonspecific (n = 159), or SSc pattern (n = 246). In people with RP and those with connective tissue diseases other than SSc, SSc pattern on NCM is prevalent. It is connected with a greater incidence of abnormal PFT, regardless of the diagnosis of SSc. While these data require validation in a prospective setting, they highlight the importance of NCM in RP and putative value to stratify the risk of pulmonary involvement in early disease stages.
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