Qu J, Zhu HH, Huang XJ, et al. - Liver and kidney function has been damaged by coronavirus disease 2019 (COVID-19) patients, especially severe patients. It has been reported that alanine aminotransferase (ALT), aspartate aminotransferase (AST), LDH, and urea nitrogen (BUN) could be independent factors for predicting the severity of COVID-19. In COVID-19 patients, combining the albumin (ALB), ALT, BUN, and LDH could predict the transition from mild to severe.

• The study recruited a total of 266 COVID-19 patients, including 235 mild patients and 31 severe patients.

• Severe patients had lower ALB and higher ALT, AST, and BUN in comparison with mild patients.

• Via binary logistic regression analysis, ALB [OR=0.273 (0.079– 0.947), p=0.041] and ALT [OR=2.680 (1.036– 6.934), p=0.042] were also distinguished as independent factors of severe COVID-19 patients.

• The results showed that the combining ALB, ALT, BUN, and LDH showed the area under ROC at 0.914, with a sensitivity of 86.7% and specificity of 83.0%.