Kim HJ, et al. - Experts sought to compare the 5-year effectiveness and recurrence rates of ablative fractional laser-assisted methyl aminolevulinate photodynamic therapy (AFL-MAL-PDT) and conventional MAL-PDT for the treatment of lower extremity Bowen’s disease (BD). They evaluated the efficacy, recurrence rates, and risk factors for unsuccessful treatments. For patients with lower extremity BD lesions, significantly higher long-term efficacy and lower recurrence rates were demonstrated by AFL-MAL-PDT vs standard MAL-PDT. The independent factors for treatment failure were the diameters larger than 20 mm and lesions with a history of previous treatment.