Zhang Z, et al. - Using data from The Cancer Genome Atlas (TCGA), the researchers described the clinicopathological significance as well as the prognostic role of Stress-Inducible Phosphoprotein1 (STIP1) in colorectal cancer (CRC). Immunohistochemical staining was also used to detect STIP1 expression in one hundred forty-four formalin-fixed, paraffin-embedded (FFPE) CRC tissue samples and determine the clinical significance of STIP1 expression in CRC. In patients with CRC, Kaplan–Meier analyses showed that higher STIP1 expression predicted a worse prognosis and Cox regression analysis exhibited that STIP1 was an independent prognostic factor for overall survival and disease-free survival. Results of this study suggested that STIP1 acts as an oncogene in CRC, thereby, serving as a biomarker for the prognosis of patients with CRC.