Li H, et al. - Based on The Cancer Genome Atlas, researchers obtained differentially expressed long non-coding RNAs (DElncRNAs) and mRNAs (DEmRNAs) between laryngeal squamous-cell carcinoma (LSCC) and adjacent tissues in order to assess key long non-coding RNAs biomarkers for LSCC. LSCC and adjacent tissues yielded 1,103 DEmRNAs and 306 DElncRNAs. They obtained a total of 338 DElncRNA-DEmRNA co-expression pairs and 229 DElncRNA-nearby-target DEmRNA pairs. For LSCC, they identified a high diagnostic value of 10 DElncRNAs and 6 DEmRNAs. HOXB9 was noted to be potentially prognostic for LSCC. In line with these results, GSE84957 validation yielded generally consistent results. These findings may help to understand the mechanism and developing potential biomarkers for LSCC.