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Abdominal imaging of pancreatic cysts and cyst-associated pancreatic cancer in BRCA1/2 mutation carriers: A retrospective cross-sectional study

Journal of the American College of Surgeons Nov 06, 2019

Cao CX, Sharib JS, Blanco AM, et al. - In BRCA-tested patients, the prevalence of pancreatic cysts (PCs) was determined. Further, an investigation was done determining rates of pancreatic adenocarcinoma (PDAC) when PCs are found in BRCA-carriers. In this retrospective cross-sectional study, PC was identified in 4,045 patients among 128,164 unique patients with abdominal imaging; these comprised 33 patients with PCs in 1,113 BRCA-tested patients. The analysis revealed similar rates of PCs, high-risk features in the cysts, and PDAC among BRCA+ patients vs BRCA- and untested patients. Hence, among BRCA+ patients, no necessity for dedicated abdominal imaging is required to evaluate for PCs and similar management guidelines should be followed as for the untested general population if an incidental PC is identified.
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