Veiga DR, et al. - Researchers conducted a prospective cohort study with two years follow-up among chronic noncancer pain (CNCP) patients in order to describe the trends and patterns of opioid therapy among these patients over this follow-up period. Further, they examined the predictors of long-term opioid use and clinical outcomes. Among 674 recruited CNCP patients, 402 (59.6%) were opioid prescriptions at baseline, and 13% (N = 86) were strong opioid prescriptions. At 24 months, as high as 74.3% (N = 501) opioid prescriptions were prevalent, and 31% (N = 207) were strong opioid prescriptions. During the two years of follow-up, 71% of opioid users (N = 479) maintained their prescriptions and there was very low opioid discontinuation (1%, N = 5) despite the limited improvement of clinical outcomes. At baseline and after two years of follow-up, higher severity and interference pain scores were reported among opioid users. They observed an independent association of continuous pain, pain location in the lower limbs, and higher pain interference scores with opioid use. Results underscore that clinical practice requires changes.