Stessuk T, et al. - Researchers sought to determine the therapeutic effects of using a biomembrane composed of autologous mesenchymal stromal cells (MSCs) and Platelet-rich plasma (PRP) on chronic wounds of diabetic patients (pre-post pilot study). In six diabetic patients with chronic wounds for more than 6 months, they performed adipose tissue collection for isolation of MSCs, blood collection for PRP preparation, and topical administration of a biomembrane of MSCs and PRP on each chronic wound. They noted granulation tissue formation beginning from 7 days after topical application. Five of the 9 lesions treated exhibited total re-epithelialization and the mean wound healing rate (WHR) was 74.55% (±32.55%) after 90 days. They identified no cicatricial hypertrophy or retraction. Findings thereby suggest good-tolerability towards mesenchymal stromal cells topical therapy associated with PRP and its ability to produce a reduction in ulcer area of diabetic chronic wounds.