Gagno S, Poletto E, Bartoletti M, et al. - Given the pivotal role of the host immune system in epithelial ovarian cancer (EOC) pathogenesis and progression, researchers evaluated the clinical importance of 192 single nucleotide polymorphisms (SNPs) on 34 immune-system related genes in advanced EOC patients (n = 230) managed with platinum-based chemotherapy. They found a significant link of 19 polymorphisms with overall survival (OS), as well as of 17 and 20 polymorphisms with progression-free survival (PFS) and platinum-free interval (PFI), respectively. Among the 8 polymorphisms related to all three outcomes, 7 SNPs belonged to genes implicated in the TGF-β pathway. Taking the unfavourable genotypes (UGs) of these 7 polymorphisms into account, they developed a genetic score (group 0–2 UGs: presence of 0, 1, or 2 UGs; group 3–4 UGs: 3 or 4 UGs; group 5–7: 5, 6, or 7 UGs). As per this score, a reduction in OS occurred as the number of UGs increased. For PFS and PFI, they noted the same trend. In permutation analysis, they validated the score. Findings are suggestive of the possible usefulness of the proposed TGF-β pathway score for defining prognosis and platinum sensitivity of advanced EOC patients.