Pomeroy E, Fenelon C, Murphy EP, et al. - The present study was conducted to describe the outcomes of total knee arthroplasty (TKA) in these patients, including survivorship, complications, and surgical considerations. Researchers conducted a systematic review of articles applying PubMed, Cochrane Central, EMBASE, and Google Scholar. They further included all studies reporting outcomes of TKA in patients with Parkinson disease, multiple sclerosis, poliomyelitis, Charcot joint, spina bifida, stroke, and cerebral palsy. A total of 38 studies were enrolled: 22 studies (461 patients) reported patient-reported outcome measures and 24 studies (510 patients) reported survivorship. In patients with neurologic disorders, TKA improves symptoms and function but carries significant risk. This study guides surgeons to preoperatively counsel their patients in an informed manner. The results consider that careful planning, perioperative care, and appropriate implant selection may mitigate the risk of complications.