Ruiz-Adame M, et al. - A systematic review was conducted to explore published evidence regarding indirect costs of fragility fractures (FF). A sum of 295 papers were observed about costs and osteoporosis between 1998 and 2019. Only 16 papers fit the criteria of selection after an iterative process. Multiple fractures, older age, and low socioeconomic profile indicate higher costs. Applying the human capital methodology, most studies are performed. The indirect costs (IC) are between 2 and 50% depending on the sample and methodology. The direct costs correlated with FF generally far outweigh the IC. Researchers demonstrated that there is a lack of knowledge about the impacts of treatments and adherence and about the dependency system. In coming generations, the changing role of women will raise indirect costs.