Aiyer R, et al. - The efficacy of N-methyl-D-aspartate receptor (NMDAR) antagonists for neuropathic pain (NeuP) was investigated. Researchers also reviewed the literature to determine if specific pharmacologic agents provide adequate NeuP relief. Researchers identified a variety of NMDAR antagonist agents (ketamine, methadone, amantadine, memantine, dextromethorphan, valproic acid, carbamazepine, and phenytoin) that showed some efficacy and should be considered for treatment of NeuP. Nonetheless, continued and further investigation of the 8 pharmacologic agents is needed to continue to evaluate their efficacy for treatment of NeuP.