Bongomin F, et al. - Considering that prolonged use of fluconazole can exert selection pressure in favour of fluconazole-resistant strains, researchers evaluated the prevalence of fluconazole resistance in Cryptococcus spp. clinical isolates in 29 studies from 1988 to May 2017 included in EMBASE and MEDLINE databases. A total of 4,995 Cryptococcus isolates from 3,210 patients constituted this study; this analysis included 248 (5.0%) of the isolates from relapsed episodes of cryptococcosis. In Cryptococcus isolates from patients with relapses, fluconazole resistance has appeared to be a matter of concern. Whether relapses occur due to resistance or other factors remained unclear.