Leopardi M, Bisogno F, Maggipinto A, et al. - In this systematic literature review, the researchers sought to determine the progression of contralateral stenosis after carotid endarterectomy (CEA) and the risk of occurrence of transient ischemic attacks (TIAs) or strokes. They conducted a systematic literature review to identify randomized controlled trials and observational studies reporting outcomes of patients treated with CEA and with concomitant contralateral carotid stenosis, irrespective of their stenosis degree. The sample consisted of 7,679 patients. The progression of contralateral carotid stenosis has been identified in a significant number of patients treated with CEA and baseline carotid stenosis. The finding indicates that patients with moderate contralateral carotid stenosis show more rapid progression to significant or symptomatic stenosis compared with patients with mild contralateral stenosis.