Jimenez XF, et al. - Researchers performed a systematic review of all studies examining atypical antipsychotics (AAs) use for pain. They used 3 literature databases to search for word combinations of “pain” and a variety of commonly prescribed AAs ie, (olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone, clozapine, paliperidone, iloperidone, lurasidone) and recognized only a few studies evaluating the analgesic effects of AAs. In multiple studies evaluating olanzapine in pain syndromes, preliminary and consistent efficacy of olanzapine in fibromyalgia and headache/migraine was noted. Other AAs eg, (quetiapine) failed to demonstrate efficacy in pain syndromes and/or lack robust study designs.