Karlow N, et al. - In this systematic review and meta-analysis, whether or not low-dose ketamine (LDK) is an effective and safe opioid alternative for acute pain reduction in adults in the Emergency Department (ED) setting was investigated. Researchers identified 3 studies that met the inclusion criteria for this meta-analysis. Ketamine was identified to be non-inferior to morphine in terms of controlling acute pain. No study reported severe adverse events, however, higher rates of nonsevere adverse events were evident with ketamine.