Langston ME, Horn M, Khan S, et al. - Earlier meta-analyses that have estimated summary positive links between clinical prostatitis and prostate cancer have not accounted for detection bias, the likelihood for increased prostate cancer screening, or detection in men with clinical prostatitis, in their pooled estimates. Therefore, researchers of the current systematic review and meta-analysis evaluated data from studies that examined the link between clinical prostatitis and prostate cancer through November 2018. They used random effects meta-analysis to estimate summary ORs among all studies and in strata defined by methods used to attenuate detection bias. In all 38 eligible studies combined, men with a history of clinical prostatitis had increased odds of prostate cancer. In studies that performed the most rigorous analyses to limit detection bias, the attenuation of this estimate to null was reported. Overall, detection bias appeared to be the possible cause of previously reported positive links between clinical prostatitis and prostate cancer.