Zhang X, Pang H, Dong Y, et al. - A total of 96 adult females who underwent dynamic contrast-enhanced MRI (DCE-MRI) between September 2017 and December 2017 were involved in this study by the researchers in order to examine the impact of menstrual status and age on the perfusion of pelvic bone marrow in adult females using quantitative DCE-MRI. Of the volume transfer constant (K^trans), efflux rate constant (K_ep), and interstitial volume (V_e) values, the intraclass correlation coefficients were 0.989, 0.974, and 0.920, respectively. In comparison to those of the postmenopausal group, K^trans, K_ep, and V_e of the premenopausal group were significantly higher. The overall age was negatively related to K^trans, K_ep, and V_e. In the premenopausal group, K^trans and V_e were significantly higher in subgroup 1 (≤ 40 years) vs subgroup 2 (> 40 years), and age exhibited a negative relationship with K^trans and V_e. In the postmenopausal group, K^trans and K_ep were significantly higher in subgroup 3 (≤ 60 years) vs subgroup 4 (> 60 years), and age demonstrated a negative association with K^trans and K_ep. Thus, in adult females, menstrual status and age have important impacts on the perfusion of the pelvic bone marrow microenvironment and that the microenvironment of the pelvic bone marrow reveals various alterations at distinctive age stages. Moreover, quantitative DCE-MRI has given to the understanding of the pelvic bone marrow perfusion status.