Sardana K, et al. - Researchers evaluated female acne patients 25 years of age and older for clinical hyperandrogenism (HA) in order to contrast the clinical and hormonal profiles of the two acne subtypes and evaluated the likely source of androgen excess – ovarian or adrenal. Hormonal assessment involved total testosterone, sex hormone-binding globulin, free androgen index, anti-Mullerian hormone, 17-hydroxyprogesterone, dehydroepiandrosterone sulfate, follicle-stimulating hormone, luteinizing hormone, thyroid-stimulating hormone, and prolactin. In a total of 120 cases, clinical HA was observed in 71.67% while biochemical hyperandrogenemia was identified in only 18.33% of people. Overall, persistent acne people had marked clinical HA, PCOS, and hormonal abnormalities necessitating an endocrinological evaluation. Moreover, as a corollary, this subgroup would benefit from antiandrogen therapy.