Wahl AM, et al. - Given their previous work demonstrating a long-lasting neuroplasticity effect mitigating the burn injury (BI)-induced secondary hyperalgesia areas (SHA)-response in the hyperbaric oxygen therapy (HBOT)-preconditioned group of BI model, researchers sought to confirm these findings via conducting an examiner-blinded, block-randomized, controlled, crossover study including 19 healthy individuals. Two BI-sessions were attended by the individuals; inter-session interval was of ≥ 28 days. Using a contact thermode (12.5 cm², 47C°, 420 s), BIs were induced on the lower legs of the participants. They block-randomized the participants to receive HBOT (2.4 ATA, 100% O², 90 min) or ambient conditions ([AC]; 1 ATA, 21% O₂), dividing cohorts equally into two sequence allocations: HBOT-AC or AC-HBOT. Outcome data establish an association of a single HBOT-session vs control with both acute and long-lasting mitigating effects on BI-induced SHA. This confirms that hyperbaric oxygen therapy has central anti-inflammatory, neuroplasticity effects.