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A single center observational study of the clinical characteristics and short- term outcome of 20 kidney transplant patients admitted for SARS-CoV2 pneumonia

Kidney International Apr 19, 2020

Alberici F, Delbarba E, Manenti C, et al. - Researchers sought to report on the outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection in patients who have received a kidney allograft and are being treated with immunosuppression. In all 20 reported kidney transplant recipients (median age 59 years [inter quartile range 51-64 years], median age of transplant 13 years [9-20 years], baseline eGFR 36.5 [23-47.5]) with SARS-CoV2 induced pneumonia, immunosuppression was withdrawn at admission and were started on methylprednisolone 16 mg/day, all but one was commenced on antiviral therapy and hydroxychloroquine with doses adjusted for kidney function. These cases showed a rapid clinical deterioration linked with chest radiographic deterioration and escalating oxygen requirement. Hence, high risk of progression and significant mortality characterize SARS-CoV-2 induced pneumonia in this limited cohort of long-term kidney transplant patients.

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