Suzuki K, Watanabe SI, Wakabayashi M, et al. - Researchers assessed whether sublobar resection is efficacious and safe for ground glass opacity dominant peripheral lung cancer (LC) in this single-arm confirmatory trial. They registered LC with maximum tumor diameter ≤ 2.0 cm and with consolidation tumor ratio (CTR) ≤ 0.25 based on thin-section computed tomography (CT). Five-year relapse-free survival (RFS) was assessed as the primary endpoint. There were 333 patients were enrolled from 51 institutions, and 5-year RFS, was estimated on 314 patients who underwent sublobar resection. Operative modes included 258 wide wedge resections and 56 segmentectomies;  the median pathological surgical margin was 15 mm. The 5-year RFS was estimated to be 99.7%; the primary endpoint was met. No local relapse occurred. Findings demonstrated that sufficient local control and RFS was achieved by performing sublobar resection, with enough surgical margin, for lung cancer clinically resectable N0 staged by CT with 3 or fewer peripheral lesions <=2.0 cm amenable to sublobar resection and with a CTR of 0.25 or less.