Lintner K, et al. - In the present study, the researchers sought to objectively assess the impact of the once‐daily application of a serum containing both antioxidants, vitamin C, and E, and the repair peptide palmitoyl tripeptide‐38 on the face of volunteer individuals, under normal conditions of daily use, using both instrumental, and innovative self‐assessment parameters. For this analysis, women of ≥ 40 years with visible signs of photoaging applied a serum comprising l‐ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide‐38 to the face once daily for 56 days. Skin‐roughness parameters reduced significantly by 8%‐9% and individuals experienced a significant increase in skin isotropy. The research proposes a statistically important link between objectively measured and quantitative subjectively perceived benefits of the bespoke serum containing antioxidants and a matrix‐restoring peptide.