Nagant C, Ponthieux F, Smet J, et al. - The present study was conducted to evaluate the cytokine profile in patients related to Coronavirus Disease 2019 (COVID-19) severity, to develop a predictive cytokine score that can discriminate severe from non-severe cases, and provide a prognosis parameter for patients that will require intensive care unit transfer. Researchers obtained serum samples of 63 patients diagnosed with SARS-CoV-2 infection soon after hospital admission (day 0-3). Individuals were classified into five groups based on the clinical presentation, the PaO2/FiO2 ratio, and the need for mechanical ventilation. Three cytokines, IL-6, IL-8 and IL-10 were markedly higher in severe forms and in critically ill patients. Study results demonstrate that the combined IL-6*IL-8*IL-10 score at presentation was very predictive of progression to a severe form of the disease and could help improve a patient's triage and to adapt therapeutic strategy within clinical trials more accurately and efficiently.