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A robust signature of immune-related long non-coding RNA to predict the prognosis of bladder cancer

Cancer Medicine Aug 13, 2021

Lai C, Wu Z, Li Z, et al. - According to the results, this research uncovered the prognostic value of immune-related lncRNAs for bladder cancer and demonstrated that they may regulate tumor pathogenesis in various ways.

  • Researchers recruited a total of 320 differentially expressed lncRNAs.

  • Individuals were classified randomly into the training data set and the testing data set at a 2: 1 ratio.

  • Nine immune-related lncRNAs with prognostic significance were distinguished in the training data set.

  • They established a risk score model to categorize patients as high- and low-risk cohorts.

  • Compared with those in the high-risk cohort, patients in the low-risk cohort had better survival outcomes.

  • Based on the indicators including age, gender, tumor-node-metastases stage, and risk score, the nomogram was established.

  • The receiver operating characteristic curve analysis, concordance index method, calibration curve, and decision curve analysis confirmed the model's predictive performance.

  • Similar results were also achieved by the testing data set.

  • As per the findings, bioinformatics analysis implied that the 9-lncRNA signature was involved in the modulation of various immune responses, antigen processing and presentation, and T cell receptor signaling pathway.

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