A robust signature of immune-related long non-coding RNA to predict the prognosis of bladder cancer
Cancer Medicine Aug 13, 2021
Lai C, Wu Z, Li Z, et al. - According to the results, this research uncovered the prognostic value of immune-related lncRNAs for bladder cancer and demonstrated that they may regulate tumor pathogenesis in various ways.
Researchers recruited a total of 320 differentially expressed lncRNAs.
Individuals were classified randomly into the training data set and the testing data set at a 2: 1 ratio.
Nine immune-related lncRNAs with prognostic significance were distinguished in the training data set.
They established a risk score model to categorize patients as high- and low-risk cohorts.
Compared with those in the high-risk cohort, patients in the low-risk cohort had better survival outcomes.
Based on the indicators including age, gender, tumor-node-metastases stage, and risk score, the nomogram was established.
The receiver operating characteristic curve analysis, concordance index method, calibration curve, and decision curve analysis confirmed the model's predictive performance.
Similar results were also achieved by the testing data set.
As per the findings, bioinformatics analysis implied that the 9-lncRNA signature was involved in the modulation of various immune responses, antigen processing and presentation, and T cell receptor signaling pathway.
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