Liu XY, Cheng J, Chen WF, et al. - Via including 1,538 patients with achalasia treated with POEM with available follow-up data, researchers established a predictive model and created a simple risk-scoring system (Zhongshan POEM Score) to help clinicians to identify high-risk patients for clinical failure after peroral endoscopic myotomy (POEM). Study participants were randomly classified to the training cohort (n = 769) or internal validation cohort (n = 769). Using multivariate Cox regression analysis in the training cohort, a risk-scoring system was created. One hundred nine patients had a clinical failure during a median follow-up time of 42 months. Three risk factors for clinical failure were weighted with point values in the training stage: previous treatment (2 points), intraprocedural mucosal injury (2 points for type I and 6 points for type II), and clinical reflux (3 points). In patients who underwent POEM, this risk-scoring system showed good performance in anticipating clinical failure.