Pallotta N, et al. - In this prospective cohort study (January 2002–September 2014), researchers developed a simple risk-scoring system to evaluate the risk of disease progression and the need for more intensive treatment and monitoring in individual patients with Crohn’s disease (CD). This investigation included 160 patients with CD patients seen at 6–12-month interval. CD lesions, age at diagnosis < 40 years, stricturing behavior (B2), specific intestinal symptoms, female sex, body mass index measure of < 21, CDAI > 50, presence of inflammatory markers, no previous surgery or presence of termino-terminal anastomosis, current use of corticosteroid, and no corticosteroid at first flare-up were identified risk factors. Findings revealed that the identified scores provide a beneficial tool for physicians, allowing an objective prognostic assessment of individual patients with CD—including an estimation of the need for treatment adjustment.