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A retrospective study of patients with Pierre Robin sequence: Patient characteristics and their impact on clinical outcomes

International Journal of Pediatric Otorhinolaryngology Nov 17, 2019

Hamilton S, et al. - At London Health Sciences Centre, researchers conducted a retrospective chart review of 24 patients diagnosed with Robin sequence (RS), a congenital set of abnormalities of the head and neck, consisting of a hypoplastic mandible (micrognathia), a tongue that is displaced posteriorly (glossoptosis), and obstruction of the airway, in order to define the management of airway and feeding issues in children with RS and to assess how airway and feeding strategies influence important clinical outcomes. Airway surgery was performed in five patients (20.8%) and enteral feeding was required in 18 patients (75.0%). Observations revealed a substantial impact of airway and feeding difficulties on RS patient morbidity, particularly with respect to the length of hospital and ICU admission. They observed a significant correlation of airway surgery with a longer ICU admission (15.8 vs 4.3 days), a longer overall hospital admission (73.0 vs 25.2 days), a delay in introducing oral feeds (222.8 vs 11.5 days), and a higher frequency of tympanostomy tube insertions (80% vs 23.5% requiring ≥ 2 insertions). Further, they observed a significant association of Enteral feeding was significantly associated with a longer ICU admission (8.8 vs 0 days) and a longer overall hospital admission (43.9 vs 5.6 days).
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