Nesseler JP, et al. - This study was planned to determine the efficacy and tolerance of adjuvant concurrent chemoradiation (CCRT) as treatment of grade 2 and 3 (G2-3) localized extremity soft tissue sarcomas (STS) by comparing CCRT with standard adjuvant radiation therapy (RT). As per findings, CCRT seemed to have the potential for improving local control as part of a limb-preservation strategy. However, with a limited number of patients, CCRT demonstrated no improvement in either distant control or survival and increased toxicity.