Dhooria S, Chaudhary S, Ram B, et al. - Researchers compared nebulized lignocaine, lignocaine oropharyngeal spray, or their combination with regard to efficacy and safety for delivering topical anesthesia during flexible bronchoscopy. This study included consecutive 1,050 individuals (median age, 51 years; 64.8% men) who were randomly 1:1:1 assigned to receive nebulized lignocaine (2.5 mL of 4% solution), oropharyngeal spray (10 actuations of 10% lignocaine), or nebulization (2.5 mL, 4% lignocaine) and two actuations of 10% lignocaine spray. Findings revealed the superiority of ten actuations of 10% lignocaine oropharyngeal spray over nebulized lignocaine or their combination for topical anesthesia during diagnostic flexible bronchoscopy.