Chew DP, Lambrakis K, Blyth A, et al. - Researchers assessed the non-inferiority of a 0/1-hour high-sensitivity troponin T (hs-cTnT) protocol vs a 0/3-hour masked hs-cTnT protocol in suspected ACS patients presenting to the emergency department (ED) in this multi-center study. They randomized the participants to either 0/1-hour hs-cTnT (reported to the limit of detection [< 5ng/L]) vs masked hs-cTnT reported to ≤ 29ng/L assessed at 0/3-hours (standard arm). All-cause mortality and myocardial infarction (MI) were assessed as 30-day primary endpoint. The study sample had a median age of 59 (49-70) years and comprised 47% female. A more rapid discharge of suspected ACS patients was reported in correlation with the use of a 0/1-hour hs-cTnT protocol. The chance of undergoing functional cardiac testing was less among those treated using the 0/1-hour protocol. Findings revealed the non-inferiority of the 0/1-hour hs-TnT protocol vs standard care, although an increase in myocardial injury was reported. A negative predictive value of 99.6% was displayed by the 0/1-hour protocol for 30 day death or MI among patients discharged from ED. There will be a need for growth in management strategies for patients with newly recognized troponin T elevation so that short term results among these patients could be improved.