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A randomized study of cyclosporine and methotrexate with or without methylprednisolone for the prevention of graft-versus-host disease: Improved long-term survival with triple prophylaxis

Cancer Nov 10, 2017

Ruutu T, et al. - In this randomized study of cyclosporine and methotrexate with or without methylprednisolone for the prevention of graft-versus-host disease (GVHD), researchers performed a long-term follow-up to discover possible late effects of the intensified GVHD prophylaxis. Findings suggested higher long-term survival among the patients given methylprednisolone (MP) in addition to cyclosporine and methotrexate. The group not given MP indicated marked late nonrecurrence mortality. The addition of corticosteroid seemed to cause no adverse late effects.
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