Friedman BW, et al. - In this randomized, sham-controlled trial, researchers tested the premise that bilateral greater occipital nerve block (GONB) with bupivacaine would provide greater rates of headache freedom than a sham injection among a population of Emergency Department (ED) patients who reported persistence of a moderate or a severe headache despite standard treatment with intravenous metoclopramide. The findings from the present study suggested that GONB might be an effective treatment for ED patients with an acute migraine who continue to suffer from a moderate or a severe headache after administration of intravenous metoclopramide. Due to slow enrollment, this investigation was stopped before achieving the a priori sample size.